Scientific Program

Conference Series LLC Ltd invites all the participants across the globe to attend 12th International Conference on Pediatric, Perinatal and Diagnostic Pathology Toronto, Ontario, Canada.

Day 2 :

Keynote Forum

Regina Fölster-Holst

President of the European Society for Pediatric Dermatology

Keynote: Paraviral exanthems in childhood

Time : 10.00 AM-12.30 PM

Pediatric Pathology 2018 International Conference Keynote Speaker Regina Fölster-Holst photo
Biography:

Dr. Regina Fölster-Holst is Professor at the Department for Dermatology, Venereology and Allergology at the Universitätsklinikum Schleswig-Holstein, Campus Kiel, Germany. She obtained her medical degree at the Christian-Albrechts-Universität, Kiel and is board certified in dermatology and allergology. She is a member of the German Dermatology Association (DDG), where she leads the Society of Pediatric Dermatology. She is executive board member of the European Society of Pediatric Dermatology (ESPD), a member of the Institute for Medical and Pharmaceutical Examination (IMPP) and engaged in the occupational union of the German Dermatologists e.V. (BVDD).

Her scientific focuses are paediatric dermatology, allergic diseases and parasitoses, whereas the main trust of her research is in atopic dermatitis, with special research expertise in immunological and biochemical activity markers, prognostic criteria, epidemiological researches and new therapeutical strategies.

Prof. Dr. Regina Fölster-Holst has received numerous awards, such as the Hans-Karrer-Förderpreis (medical brochure for children) in 1997, the “Preis der Hensel Stiftung” (1998), theTeaching Award of the Medical Faculty of Kiel (2003), the German scientific award for communication and the Perle-Award.

Abstract:

Exanthems are common skin diseases in childhood and are usually related to viral infections. The infection triggers the exanthema directly (e. g. varicella, herpes simplex, enteroviruses), via an immune response (paraviral exanthems as Gianotti-Crosti-syndrome, Pityriasis rosea) or by interactions with drugs (e. g. amoxicillin exanthem in patients with infectious mononucleosis).

Paraviral exanthems are distinct skin diseases related to infections with different viruses. While many viral infections are a direct result of the infection, paraviral exanthems reflect the response of the immune system to the viruses, which cannot be identified in the skin. Typical paraviral exanthems include Gianotti-Crosti syndrome, Pityriasis rosea, Pityriais lichenoides, Papular-purpuric gloves and socks syndrome, and asymmetrical periflexural exanthema. Unilateral mediothoracic exanthema, eruptive pseudoangiomatosis are not so common and eruptive hypomelanosis have been described recently.

  • Pediatric Orthopedics
Location: 1

Session Introduction

Mercede Enshaei

M.D, Gilan University School of Medical Sciences, Iran

Title: Iron Status Profile in Children with Hyperkinetic Movement Disorders: A Comparison with Normal Children
Biography:

Mercede Enshaei has completed her Pediatric Specialty at the age of 32 years from Gilan University of Medical Sciences. She studied Genetic Counseling at Tehran University of Medical Sciences, and she will begin the Pediatric Hematology and Oncology Subspecialty from September 2018. 

Abstract:

Movement disorders are a growing field of pediatric neurology. Unlike adults, it seems children are more likely to suffer from hyperkinetic movement disorders. Some studies have been done on serum iron in affected adults, but there are limited data in pediatrics. This survey case-control study was aimed to compare iron profiles in children with hyperkinetic movement disorders with healthy children.

We evaluated 50 children 2-12 years of age with hyperkinetic movement disorders including 18 tic disorders, ten dystonia, 8 chorea, 6 myoclonus, 3 stereotypies, 3 athetosis (with a history of neonatal kernicterus) and 2 tremor; 26 male and 24 female with mean age of 8.2±2.37 (2-12) years.  Fifty healthy children as age and sex-matched controls were enrolled too. In children with hyperkinetic movement disorders serum iron, TIBC, and serum ferritin were 51.8 ± 2.77µg/dl, 450± 9.42 µg/dl and 47.92 ± 7.87 ng/ml; while in normal children these amounts were 81.4±3.94 µg/dl, 356 ± 12.34 µg/dl and 140.68 ± 13.61 ng/ml respectively. The differences of each parameter between two groups were statistically significant. (P-value < 0.05)

There was a significant difference between patients with hyperkinetic movement disorders and healthy controls regarding iron profiles. Our findings suggest that decreased blood iron levels may have a predisposing effect on hyperkinetic movement disorders, although the knowledge about the mechanism is still limited. Since these disorders affect the quality of life, it seems further studies are needed to understand the mechanism and make some recommendations on prevention or control of the disease.

 

  • Perinatal/ Neonatal Pathology
Location: 2

Session Introduction

FATIHA BENNAOUI

Assistant Professor of Pediatrics, Neonatal Intensive Care Unit , Mother and Child Hospital, Mohammed VI Marrakech University Hospital, Morocco.

Title: Mothers of preterm infants hospitalized in neonatal intensive care: Study of the circumstances
Biography:

FATIHA BENNAOUI is an Assistant Professor of Pediatrics, graduate in Neonatal-Perinatal Medicine from Medecine School ; Cadi Ayad University ; Marrakesh, and health services researcher in the section of General Pediatrics. She leads the faculty and post-doctoral fellows in Neonatology, in Newborn Intensive Care Units at University Hospital ; Marrakesh. In addition, she is actively involved in the perinatl education of Yale medical students, attending physicians, fellows, residents, nurses, and physician associate students, she has for many years served as medical faculty. She has more than 5 years of experience as a clinical neonatologist and over 10 years of experience in pediatric medicine.

Dr. BENNAOUI has been an invited lecturer nationally and internationally, focusing on analyse of pediatric medicine. She has many publications ; more than 12 papers indexed in scopus and in pubmed. She has served on the Moroccan Association of Pediatrics.

Abstract:

Introduction: Prematurity is a common condition. It is responsible in Morocco for a morbidity and neonatal mortality rate.

Objective: The objective of the study is to assess the conditions of women who give birth prematurely

Materials and methods: All preterm infants hospitalized during the year 2016 were included in this study. The analysis of the files identified the different parameters’ mothers.

Results: The rate of admission of premature babies to the service is 19%. The most common maternal age was between 18 and 35 years of age (80%). 68% of women are multiparous, and more than 40% of women have a history of miscarriage. Pregnancy was not followed in 27% of cases, antenatal corticosteroids were administered in 45% of cases, pregnancy was multiple in 25%, premature rupture of membranes was noted in 36% of cases, and maternal infection was 33%. Birthing was predominant with a rate of 73%. The majority of premature babies admitted to the service (64%) come from birth delivered at the university hospital center.  Non-induced prematurity accounts for the majority of cases with 78% of cases. The overall prematurity mortality rate is 62% among all preterm infants

Conclusion: Prevention would reduce the rate of prematurity and improve its management, especially through close obstetric-pediatric collaboration.

FATIHA BENNAOUI

Assistant Professor of Pediatrics, Neonatal Intensive Care Unit , Mother and Child Hospital, Mohammed VI Marrakech University Hospital, Morocco.

Title: Blood culture : bacterial infections of newborns admitted from maternity
Biography:

FATIHA BENNAOUI is an Assistant Professor of Pediatrics, graduate in Neonatal-Perinatal Medicine from Medecine School ; Cadi Ayad University ; Marrakesh, and health services researcher in the section of General Pediatrics. She leads the faculty and post-doctoral fellows in Neonatology, in Newborn Intensive Care Units at University Hospital ; Marrakesh. In addition, she is actively involved in the perinatl education of Yale medical students, attending physicians, fellows, residents, nurses, and physician associate students, she has for many years served as medical facultyShe has more than 5 years of experience as a clinical neonatologist and over 10 years of experience in pediatric medicine.

Dr. BENNAOUI has been an invited lecturer nationally and internationally, focusing on analyse of pediatric medicine. She has many publications ; more than 12 papers indexed in scopus and in pubmed. She has served on the Moroccan Association of Pediatrics.

Abstract:

Blood culture provides an undeniable ideal aid in the diagnosis of neonate infection, its result is reliable. The aim of our study was to evaluate the bacteriological profile of bacteremia, admitted newborns from maternity hospital IBN TOFAIL.

Retrospective study on the cases of newborns hospitalized in the neonatal intensive care, University hospital Mohamed VI,Marrakesh, originating from the delivery room of the gynecology-obstetric department IBN TOFAIL, over a period of 6 months, June to November 2016.Of the 125 blood cultures collected, 43 were positive, representing an over all positivity rate of 34.4%. Positive staphylococcal coagulase negative hemocultures were 27. Other bacteremias were 16, consisting essentially of multiresistant germs with the predominance of Klebsiella pneumoniae (5 cases), followed by Acinetobacter Baumanii (4 cases) and Serratia marcescens in 3 cases.

The bacteremia on admission ; especially to multiresistant germs presents a major problem of therapeutic management.We emphasize the necessity to improve the conditions of delivery in our context and to develop new diagnostic and therapeutic strategies.

  • Pediatric Urogynecology
Location: 3
Speaker
Biography:

Dr Sura Al-Rawabdeh a senior specialist in Pediatric pathology working in the royal medical services in Jordan.She got  fellowship training in pediatric pathology. In nationwide children’s hospital Columbus Ohio USA 

Abstract:

The patient is an 11-year-old boy who presented with a 1-day history of abdominal pain and emesis but no fever. His past medical history was unremarkable. In particular, there was no history of hemorrhagic problems or systemic disease. The family history was also unremarkable. On physical examina- tion, he had persistent and well-localized right lower quad- rant and right flank tenderness at the expected location of his appendix (McBurney’s point). The laboratory findings were unremarkable. WBC was 4.9 K/microliter with the following differentials: 49% segmented neutrophils, 41% lymphocytes, 9% monocytes, and 1% eosinophils. There was no evidence of anemia or thrombocytopenia (hemoglobin = 13 g/dL, hematocrit = 36%, and platelet count = 291 K/microliter). A computed tomography scan (CT-Scan) of the abdomen showed an enlarged appendix without inflammation; how- ever, ultrasound images showed a fluid-filled appendix with a diameter within the upper rages of normal. A subsequent physical examination revealed an increase in abdominal pain and tenderness, and, consequently, the patient underwent a laparoscopic appendectomy.

Gross evaluation showed a pink-tan appendix, measuring 8.3 cm in length and 1 cm in diameter. The serosal surface was unremarkable and cut surface demonstrated no fecalith. Microscopically, hematoxylin-eosin-stained sections of the tip of the appendix revealed numerous lipid-laden xanthoma cells in the mucosa which were surrounded by lymphocytes and plasma cells admixed with multiple mult- inucleated giant cells containing cholesterol clefts.The rest of the mucosa showed patchy mild neutrophilic infiltration.

The postoperative clinical course was unremarkable. The patient was discharged home the following day and had an unremarkable physical examination on a follow-up visit three weeks later

Biography:

Abstract:

Background: Varicocele is generally considered the most common correctable cause of male infertility. Testicular disproportion is considered to be the most important sign of testicular damage in absence of the possibility to do routine semen analysis in adolescent.

Aim: The aim of our work is to evaluate feasibility, recurrence rate and postoperative complications of laparoscopic varicocelectomy with preservation of the testicular artery in adolescents.

Patient and methods: Our prospective clinical study was done between May 2016 and May 2017 at pediatric surgery unit, General Surgery Department, Tanta University Hospital. The study included twenty patients presented with symptomatic varicocele. Then, laparoscopic varicocelectomy with preservation of the testicular artery were done for all cases. Operation time, the success rate, the incidence of complications, the length of the hospital stay, conversion and data of follow up were recorded.

Results : Total Operation time ranged between 10 and 40 minutes. There were testicular catch up growth in 5 cases and we had no testicular atrophy in the other cases Recurrence occurred in 2 cases in the period of follow up (6 months).

 

  • Pediatrics & Neuropsychology
Location: 4
Speaker
Biography:

Dr Hiba A. Awooda is an Assistant Professor at the department of physiology, faculty of medicine. She successfully completed her master and Ph.D in the feild of neuropphysiology from Alexandria University (2011) and Al Neelain University (2013) respectively. As well as master of medical education from University of Khartoum. She teaches physiology to undergraduate medical, dental, physiotherapy and nurse students. She is also a researcher with interest in developing biomarkers that are used in the treatment of acute ischemic stroke. She has published more than 20 papers in reputed journals

Abstract:

Role of nitric oxide (NO) inhibition in cerebral ischemia/reperfusion (I/R) remains uncertain; this work aimed to explore the neuroprotective potential of N-Nitro-L-Arginine-Methylester (L-NAME) non-selective NO synthase (NOS) inhibitors.The study involved 30 adult male Wistar rats (150-250g), divided into three groups;10 rats in each: sham-operated group (control), I/R group: infused with 0.9% normal saline intraperitoneally prior to 30 minutes of left common carotid artery occlusion followed by 24-hour of reperfusion, third group (test group): infused with L-NAME (15 mg/kg per weight) intraperitoneally 15 minutes prior to the same I/R period. Neurobehavioral assessments were evaluated using six clinical tests. Proper anesthesia was induced. Western blotting was used to estimate Nuclear factor kappa B (NF-қB), Tumor necrosis factor-α (TNF-α) using ELISA and NO metabolites (nitrite and nitrate), were measured colorimetrically in both plasma and affected cerebral hemisphere. Result shows that L-NAME group demonstrates a significant improvement in neurological deficit (P <0.001) compared to both I/R and control groups. In I/R rats NF-қB was significantly increased compared to the control group and L-NAME pretreatment resulted in a significant decrease in NF-қB (P <0.001) compared to I/R group. Serum level of TNF-α and NO were significantly increased in I/R group compared to the control group (P <0.001), while L-NAME administration resulted in a significant decrease in serum TNF-α and NO (P <0.001) compared to the I/R group. In conclusions L-NAME pretreatment for rats undergoing cerebral ischemia/reperfusion significantly improve neurological deficit through it is anti-inflammatory effect in a rat’s model of transient focal cerebral ischemia reperfusion.

Madineh Hassani

M.A of Occupational Therapy, Occupational therapy Clinic, Paveh, Iran

Title: Social Participation in Children with Cerebral Palsy
Biography:

Madineh Hassani  has completed his MA at the age of 25 years from Tehran University of Medical Sciences,she has been Graduated from Shahid Beheshti University of medical sciences, as Bachelor, with the specialties including Occupational Therapist (Rehabilitation and then started working at The Tabriz University of medical sciences as lecturer where she has continued his research. Presently he has been working at the at the Paveh City in Ocuupational Therapy Clinic

Abstract:

Objective: Since the according to International Classification of Functioning, Disability and Health (ICF) participation is the ultimate outcome for individuals with disabling conditions, Children with cerebral palsy are at risk of reduced participation in everyday activities, Purpose of this study is review of Life habits according ICF in children with Cerebral palsy.

Materials & methods: In this cross sectional study 53children with cerebral palsy (5-13 years old) from rehabilitation centers were selected via the non-probability convenience sampling. The quality of accomplishment of life habits and the overall satisfaction with performance were assessed via Life-H Questionnaire through interviews with parents. Life habits divided into 12 categories. The categories nutrition, fitness, personal care, communication, housing and mobility refer to daily activities; the categories responsibilities, interpersonal relationships, community life, education employment and recreation address social roles.

 

 

Biography:

I am Yasir Alrashdan, 23 years old , 5th year medical student at Hail University, medical college. I have done some research with Dr. M. Parvaiz Farshori who has many important researches at medical filed.This is my 2nd personal research and I hope to present it at your conference.

 

Abstract:

Hyponatremia manifests most commonly with neurologic dysfunction and results more from the rate of change of sodium concentration. This review discusses the recent evidence concerning the pathophysiology, risk factors and treatment techniques. We performed detailed search through electronic databases; PubMed, and EMBASE, for studies published in English language and human subjects thought instant to 2017. Studies discussing the acute hyponatremia in pediatrics, management approaches. Hyponatremia is a severe adverse event that can be avoided with proper
IV fluids option and cautious monitoring. Because hospitalized children are at an increase danger for hyponatremia secondary to nonosmotic stimulus that could stimulate the release of ADH, isotonic intravenous (IV) fluids appears to be a safer empirical option. The studies discussed demonstrate that the use of isotonic IV fluids could decrease the risk of hospital-acquired hyponatremia. There is proof to sustain that hypotonic saline solutions could trigger acute hyponatremia, which may result in severe unfavorable effects and even fatality, especially in postoperative patients. Like all drugs, there is no ideal IV fluids for all kids, so response to IV fluids therapy need to be observed closely. When hypotonic saline is utilized health care providers need to be educated on the signs and symptoms associated with acute hyponatremia.

 

  • Pediatric Dermatology
Location: 5
Biography:

Marjan  Entezami  has completed her medical doctorate at the age of 25 years  from Islamic Azad University Tehran Faculty of Medicine, Iran. She is working as a general practitioner in the emergency department of Tafresh  Hospital , Arak ,Iran .Her thesis about “comparison of the therapeutic effects of UVB and  PUVA therapy in patients with vitiligo” was published in online Skin and Beauty Magazine in 2017.

 

Abstract:

Abstract:

Background : Vitiligo is a common pigmentary  disorder with great cosmetic and psychological morbidities . Although many  treatment modalities have been tried for the treatment of vitiligo , none is uniformly effective. PUVA (Psoralen Ultra Violet A) is established as efficacious treatment for vitiligo. Recently, narrow band UVB(NBUVB) has been reported to be an effective and safe therapeutic  option in patients with vitiligo. In this study, patients with vitiligo  divided into two groups that   were treated either with UVB or PUVA therapy modalities and the efficacy ,the time required for repigmentation, stability of repigmentation and adverse effects were compered in two groups.

Methods: A clinical trial has been performed on 60 patients with vitiligo referred to BOUALI hospital  and MEHREGAN laser center in 1392 and  treated with UVB and PUVA therapy methods.

In first group that were  treated with PUVA (30 patients), oral   tablets containing 8-methoxypsoralen at a dose of 25 mg/ m2 were taken 3 hours  before  phototherapy and PUVA therapy was started at a dose of 0.5 J/cm2 twice a week. The phototherapy dose was increased by 20%  in each visit  if tolerated.

In second group( 30 patients) , UVB therapy was administered twice a week  with 311-313 nm wavelength and a dose of 0.1 J/cm2 and we increased the dose 20% in each visit if tolerated .phototherapy sessions in both groups were  15. In patients treated with PUVA , 40% were male (12 patients) and 60% were female(18 patients).In UVB group 43.3% were male (13 patients) and 56.7% were female(17 patients).The mean age in PUVA- treated group is 34 years and in UVB- treated group is 32.1 years. There was no statistically significant difference on comparing mean age in both groups.(p=0.13). Type of vitiligo in patients treated with PUVA was 56.7% generalized, 30% segmental and 13.3 % focal ,and in patients treated with UVB was 56.7 % generalized,33.3% segmental and 10% focal.