Dr. Reza Saeidi
Mashhad University of Medical Sciences
Title: The role of recombinant human granulocyte colony-stimulating factor (G-Csf) In the management of neonatal sepsis in premature infants
Biography
Biography: Dr. Reza Saeidi
Abstract
Whenever neonatal sepsis is associated with neutropenia, increase mortality and morbidity. We know in the preterm infants, neutropenia is common. In this study we evaluated effects of G-CSF administration on early onset neonatal sepsis in premature infants.
This study was performed in the College of Medicine, Mashhad University, NICU of Qaem Hospital between May 2012 and February 2013. In this study we enrolled fifty premature neonates with GA <35 weeks and a mean birth weight of 1500 ± 499g, who were under 5 days old that were admitted to NICU with the clinical diagnosis of sepsis. The study population was divided to the case (G-Csf) and control groups placebo (dextrose 5%). To analyze the data with nominal scale, Pearson Chi-Square was used. In cases which more than 20% of expected frequencies of tables were less than 5, (Cochran) Fisher's test (Fisher's Exact Test) was used. SPSS v.19 and Statistical V.8 software were used.
There was significant difference between two groups for absolute neutrophil count (ANC) in second sampling (P =0.010), but for other cases, the difference wasn’t statistically significant (P > 0.05). Also the change in absolute neutrophil counts between two blood exams showed significant difference in control group, (P = 0.006), but the difference wasn’t statistically significant in the study group (P=0.627).
Routine administration of G-CSF is not recommended as an adjuvant therapy for neonatal sepsis in non-neutropenic premature neonates.